GBL anticorps (N-Term)

N° du produit ABIN5516539

L’anticorps Lapin Polyclonal anti-GBL a été validé pour WB. Il convient pour détecter GBL dans des échantillons de Humain.

Aperçu rapide pour GBL anticorps (N-Term) (ABIN5516539)

Antigène: GBL (G protein beta subunit-like (GBL))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GBL est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-GBL anticorps

Épitope: N-Term

Séquence: TRTVQHQDSQ VNALEVTPDR SMIAAAGYQH IRMYDLNSNN PNPIISYDGV

Attributs du produit: This is a rabbit polyclonal antibody against LST8. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human LST8

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GBL

Antigène: GBL (G protein beta subunit-like (GBL))

Autre désignation: LST8

Sujet: LST8 is a subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient- poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive.

Alias Symbols: MLST8, GBL, LST8,

Protein Interaction Partner: MTOR, EIF4EBP1, RPTOR, AKT1S1, PRR5L, FKBP8, SUZ12, PRMT1, STAT1, RICTOR, UBC, ATXN1, A2M, DEPTOR, ULK1, RPS6KB1, SQSTM1, Cul4a, Dtl, PRR5, CCT2, KRT85, RHEB,

Protein Size: 326

ID gène: 64223

UniProt: Q9BVC4

Pathways: Signalisation PI3K-Akt, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, L'effet Warburg